Betamethasone Butyrate Propionate Inhibits the Induction of Thymic Stromal Lymphopoietin in Cultured Normal Human Keratinocytes
نویسندگان
چکیده
772 Ann Dermatol Received July 24, 2015, Revised October 12, 2015, Accepted for publication October 27, 2015 Corresponding author: Yutaka Hatano, Department of Dermatology, Faculty of Medicine, Oita University, 1-1 Idaigaoka, Hasama-machi, Yufu-shi, Oita 879-5593, Japan. Tel: 81-97-586-5882, Fax: 81-97-586-5889, E-mail: [email protected] This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/ licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © The Korean Dermatological Association and The Korean Society for Investigative Dermatology fact that both aforementioned skin conditions; atopic dermatitis and psoriasis involves substantial epidermal hyperplasia, in addition to PAR-2 associated sensory symptoms, most prominently itch, cutaneous inflammation and mild pain. It is unclear if PAR-2 is involved in the pathogenesis of inflammatory skin conditions or whether aberrations in PAR-2-signaling is a consequence of preceding etiological processes, which could be distinct between different pathophysiological conditions. However, PAR-2 does appear to play a significant role in skin physiology, inflammation and the related cutaneous sensory symptoms such as itch and pain. This makes the receptor an interesting pharmaceutical target for inflammatory skin diseases.
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